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Assistance Listings
Scientific Research - Combating Weapons of Mass Destruction

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Note: This Assistance Listing was not updated by the issuing agency in 2025. Please contact the issuing agency listed under "Contact Information" for more information.

Assistance Listing
Sub-tier
DEFENSE THREAT REDUCTION AGENCY (DTRA)
Assistance Listing Number
12.351

Overview

Objectives

To support and stimulate basic, applied and advanced research at educational or research institutions, non-profit organizations, and commercial firms, which support the advancement of fundamental knowledge and understanding of the sciences with an emphasis on exploring new and innovative research for combating or countering Weapons of Mass Destruction (WMD).

Examples of Funded Projects

Fiscal Year 2024: Continued to fund ongoing research projects in fundamental research as well as two cooperative agreements that encompass a consortia of universities. Research was performed in both medical and physical sciences including a deep machine-learning guided approach has resulted in five new antibiotics against antimicrobial resistance as well as a highly adaptable experimental model system capable of storing the energy of natural light to efficiently decompose chemical warfare agents in the dark and under ambient conditions. Research also furthered support of the Biological Threat Reduction Program mission to strengthen the capabilities of partner nations and the international community to prevent, detect, and prepare for outbreaks caused by high threat pathogens.

Assistance Listing Description

DTRA safeguards America and its allies from weapons of mass destruction (WMD) and provides capabilities to reduce, eliminate, and counter the threat and effects from chemical, biological, radiological, nuclear, and high yield explosives. DTRA seeks to identify, adopt, and adapt emerging, existing and revolutionary sciences that may demonstrate high payoff potential to Counter-WMD threats, including improvised threats. This endeavor combines the fundamental research, educational program, or other effort needs appropriate for basic or applied research funding of DTRA and other DoD interests.

Authorizations

10 U.S.C. 2358 (R&D Grants and cooperative agreements). 10 U.S.C. 2361 (Grants & contracts to universities-competitive). 10 U.S.C. 2371 (Transactions other than contracts and grants).

Financial Information

These funding amounts do not reflect the award amounts that are displayed on USASpending.gov
Obligation(s)FY 23FY 24 (est.)FY 25 (est.)
Project Grants Total$59,732,359$24,098,380$34,286,000
Totals$59,732,359$24,098,380$34,286,000

Range and Average of Financial Assistance

Range from $100,000 per year to $1,000,000 per year over a 5-year period.

Accomplishments

Fiscal Year 2024: Awarded several new grants in the area of chemical and biological, cooperative threat reduction, and other mission related basic research. One such award advanced research of a molecular docking system based on generative artificial intelligence machine learning for accelerated drug development is now being used in academia and industry.

Account Identification

97-0400-3-4-000-970400.34HQ

Criteria for Applying

Types of Assistance

B - Project Grants

Credentials and Documentation

Award is subject to: 1) receipt of applicable/acceptable certifications and representations; 2) having a current registration in the System for Award Management (SAM) (www.sam.gov); 3), the applicant, its principals, proposed subrecipients/subrecipient principals not appearing in SAM Exclusions as currently debarred, suspended, or otherwise ineligible; and 4) meeting other requirements specified in the agency announcements. 2 CFR 200, Subpart E - Cost Principles applies to this program.

Applicant Eligibility

Designations

Public nonprofit institution/organization (includes institutions of higher education and hospitals), Other public institution/organization, Profit organization, Private nonprofit institution/organization (includes institutions of higher education and hospitals)

As stated in individual program BAAs. Generally, competitions are open to private and public educational accredited institutions of higher education that carry out science and engineering research and/or related science and engineering education on a non-profit basis. Some awards are made to other non-profit and for profit organizations that conduct research. Awards are not made to individuals.

Beneficiary Eligibility

Designations

Profit organization, Public nonprofit institution/organization, Other public institution/organization

See above.

Length and Time Phasing of Assistance

Since this is a research and technology program, the assistance is generally for the period of performance as stated in the individual grant, agreement or TIA. Funding is usually provided incrementally in accordance with a payment schedule contained in the award document. Grants are normally a base period and option years up to five total years. Method of awarding/releasing assistance: Assistance might be released fully funded or incrementally.

Use of Assistance

Designations

Science and Technology, Civil Defense/Disaster Prevention and Relief/Emergency Preparedness

Uses and restrictions are specified in individual program BAAs and award documents issued by and codified regulations applicable to awards. These are submitted at the time of proposal or prior to award, as specified by executive agents.

Applying for Assistance

Deadlines

Review the appropriate funding announcement for due date and deadline information.

Preapplication Coordination

Preapplication coordination is not applicable. Environmental impact information is not required for this program. This program is excluded from coverage under E.O. 12372.

Application Procedures

2 CFR 200, Uniform Administrative Requirements, Cost Principles, and Audit Requirements for Federal Awards applies to this program.

Eligible applicants may submit white papers or proposals in response to relevant Broad Agency Announcements (BAA) published on Grants.gov or www.FedBizOpps.gov under "Other Defense Agencies - DTRA". Each BAA identifies to potential applicants and what activities or research topic areas will be supported, and how to apply.

Criteria for Selecting Proposals

Generally, the principal evaluation and selection criteria are the technical or socio-economic merits of the proposal and potential long term contributions of DTRA's specific mission. Other selection criteria vary with the nature of the specific research or research-related activity. Typically, these include the qualifications, capabilities, and experience of the proposed Principal Investigator and/or key personnel who are critical in achieving the proposal objectives; adequacy of current or planned facilities, and equipment; and reasonableness and realism of the proposed costs.

Award Procedure

Award decisions are based on evaluations of proposals using peer and/or scientific review. Evaluation criteria are contained in the relevant BAA. If selected for award, the proposal is the basis for the award document and the applicant agrees to perform the research or research related activities described therein.

Date Range for Approval/Disapproval

Award times will be identified in the relevant BAA. Typically, decisions are made within 90-120 days of receipt of proposal for which funding is authorized.

Renewals

Re-application with new proposals is permitted.

Appeals

Not Applicable.

Compliance Requirements

Policy Requirements

The following 2CFR policy requirements apply to this assistance listing:

Subpart B, General provisions

Subpart C, Pre-Federal Award Requirements and Contents of Federal Awards

Subpart D, Post Federal; Award Requirements

Subpart E, Cost Principles

Subpart F, Audit Requirements

The following 2CFR policy requirements are excluded from coverage under this assistance listing:

Not Applicable

Additional Information:

Reports

Program Reports: As required by Assistance Award

Progress Reports: As required by Assistance Award

Expenditure Reports: As required by Assistance Award

Audits

Refer to the link below for 2 CFR Subpart F Audit Requirements.
https://www.ecfr.gov/current/title-2/subtitle-A/chapter-II/part-200/subpart-F

Additional audit requirements:

Audit requirements for for-profit organizations, which are not subject to 2 CFR part 200, are consistent with the requirements in the DoD Grant and Agreement Regulations (DoDGARs) at 32 CFR 34.16.

Records

Record keeping requirements are in accordance with the terms and conditions of the award, which will include appropriate provisions related to recipient records that are required by the DoDGARs.

Regulations, Guidelines, and Literature

Regulations, Guidelines and Literature sources are specified in the individual relevant Broad Agency Announcements. The DoDGARS (as updated through DoD’s interim implementation of 2 CFR part 200 which can be found at 2 CFR part 1103) applies to DoD grants and cooperative agreements.

Formula and Matching Requirements

Statutory formula is not applicable to this assistance listing.
Matching requirements are not applicable to this assistance listing.
MOE requirements are not applicable to this assistance listing.

Contact Information

Regional or Local Locations:

See Regional Assistance Locations.

Headquarters Office:

Mary Kay Chase
8725 John J. Kingman Road,
Fort Belvoir, VA 22060
mary.k.chase2.civ@mail.mil
571-616-6159
Website: https://grants.gov/

History

  • 2024Published

    Scientific Research - Combating Weapons of Mass Destruction

  • 2023Published

    Scientific Research - Combating Weapons of Mass Destruction

  • 2022Published

    Scientific Research - Combating Weapons of Mass Destruction

  • 2021Published

    Scientific Research - Combating Weapons of Mass Destruction

  • 2020Published

    Scientific Research - Combating Weapons of Mass Destruction

  • 2019Published

    Scientific Research - Combating Weapons of Mass Destruction

  • 2019Agency Changed
  • 2019Published

    Scientific Research - Combating Weapons of Mass Destruction

  • 2018Published

    Scientific Research - Combating Weapons of Mass Destruction

  • 2016Title Changed

    Scientific Research - Combating Weapons of Mass Destruction

  • 2007Published

    Basic Scientific Research - Combating Weapons of Mass Destruction