Mitochondrial function analyzer

• Solicitation Number: 75N95024Q00074
• Title: Mitochondrial function analyzer

• NAICS Code:  334516 Analytical Laboratory Instrument Manufacturing

•  Description: 

This is a Small Business Sources Sought notice. This is NOT a solicitation for proposals, proposal abstracts, or quotations. The purpose of this notice is to obtain information regarding: (1) the availability and capability of qualified small business sources; (2) whether they are small businesses; HUBZone small businesses; service-disabled, veteran-owned small businesses; 8(a) small businesses; veteran-owned small businesses; woman-owned small businesses; or small disadvantaged businesses; and (3) their size classification relative to the North American Industry Classification System (NAICS) code for the proposed acquisition. Your responses to the information requested will assist the Government in determining the appropriate acquisition method, including whether a set-aside is possible. An organization that is not considered a small business under the applicable NAICS code should not submit a response to this notice.

This notice is issued to help determine the availability of qualified companies technically capable of meeting the Government requirement and to determine the method of acquisition.  It is not to be construed as a commitment by the Government to issue a solicitation or ultimately award a contract.  Responses will not be considered as proposals or quotes.  No award will be made as a result of this notice.  The Government will NOT be responsible for any costs incurred by the respondents to this notice.  This notice is strictly for research and information purposes only.

Background:  

Purpose and Objectives: The purpose of this acquisition is to procure equipment needed for the study of mitochondrial function.

Description:

The Contractor shall provide the Government with the following:

  

Item 1: Oroboros O2k-Fluo Series J 10201-03

Integrated computer with touchscreen connects DatLab to the O2k

Keyboard, webcam and webcam accessories

O2k: Hardware and DatLab Software

• Stainless steel housing
• Peltier thermostat 4 to 47 °C; ±0.002 °C
• Barometric pressure transducer
• Amperometric oxygen channels
• ISE sockets for ion sensitive electrodes
• Sockets for optical signals
• Sockets for PB-Module
• Duran glass chambers (2 mL)
• SmartPOS: Polarographic Oxygen Sensor (POS) with Connector
• PVDF stirrers, electromagnetic control
• PEEK stoppers with O-ring
• Blue POM chamber holders with O-ring and V-ring
• Blue POM OroboPOS-holders
• Current DatLab version with free follow-up upgrades within the warranty period

            O2k: Accessories and Consumables

• ISS-Integrated Suction System, to remove medium from the O2k-Chamber
• Oxia - the O2 regime controller for HyperOxia and HypOxia
• O2k-Titration Set: Hamilton microsyringes; fixed needles with rounded tips
• MiR05-Kit: Mitochondrial Respiration Medium

O2k-Fluo Smart-Module: an amperometric add-on module for measurement of hydrogen peroxide production, ATP production, mt-membrane potential, Ca2+

• Smart Fluo-Sensors, green LED emission, photodiode and filters, excitation LED 525 nm,pre-calibrated intensity
• Smart Fluo-Sensors, blue LED emission, photodiode and filters, excitation LED 465 nm,
• pre-calibrated intensity
• Filter Sets (Mg green/Ca Green, Amplex Red, Safranin) consisting of LED filters and photodiode filters

TIP2k-Module: add-on for two-channel operation with the O2k-FluoRespirometer with automatic control by DatLab of programmable titration regimes and feedback control

• Microinjection syringes, 200 mm3, 180 mm needle length, 0.12 mm inner Ø; fixed needles with rounded tips
• Needle Spacers, silicone stops (200/Pkg.) with mounting tool
• TIP2k-Needle Safety Support with cable guide
• TIP2k-Filter Papers

O2k-sV-Module: small chamber volume to reduce the sample amount needed for OXPHOS analysis and cellular/mitochondrial respiratory function

• Duran glass chambers, with smaller operation volume (V) of 0.5 cm3 (0.5 mL)
• PVDF stirrers for small volume chambers, electromagnetic control
• PEEK stoppers for small volume chambers
• Black POM chamber holders with O-ring and V-ring
• Black POM OroboPOS-holders

Item 2: Power- Oroboros O2k-Fluo Series J 10201-03P

Power Package needed to increase throughput.

Integrated computer with touchscreen connects DatLab to the O2k

Keyboard, webcam, and webcam accessories

O2k: Hardware and DatLab Software (Same as Above)

           

            O2k: Accessories and Consumables

• MiR05-Kit: Mitochondrial Respiration Medium. For a final volume of 250 mL

O2k-Fluo Smart-Module: an amperometric add-on module for measurement of hydrogen peroxide production, ATP production, mt-membrane potential, Ca2+ (Same as Above)

TIP2k-Module: add-on for two-channel operation with the O2k-FluoRespirometer with automatic control by DatLab of programmable titration regimes and feedback controlv  (Same as Above)

O2k-sV-Module: small chamber volume to reduce the sample amount needed for OXPHOS analysis and cellular/mitochondrial respiratory function (Same as Above)

1. 1. 1. Quantity: 1 each

1. 1. 1. Delivery Date: 8 weeks after receipt of award

Place of Performance:

3001 S. Hanover Street

Baltimore, MD 21225

Capability statement /information sought. Contractors that believe they possess the ability to provide the requirement should submit documentation of their ability to meet each of the project requirements to the Contract Specialist. The response should directly and specifically state in the, capabilities statement, which project requirements you can supply. Contractors must also provide their Company Name, DUNS Number, Physical Address, Point of Contact, and Size and Type of Business (e.g., 8(a), HubZone, etc.) pursuant to the applicable NAICS code and any other information that may be helpful in developing or finalizing the acquisition requirements.

One (1) copy of the response is required and must be in Microsoft Word or Adobe PDF format using 11-point or 12-point font, 8-1/2” x 11” paper size, with 1” top, bottom, left and right margins, and with single or double spacing.

The information submitted must be must be in and outline format that addresses each of the elements of the project requirement and in the capability statement /information sought paragraphs stated herein.  A cover page and an executive summary may be included but is not required.

The response is limited to ten (10) page limit.  The 10-page limit does not include the cover page, executive summary, or references, if requested.

The response must include the respondents’ technical and administrative points of contact, including names, titles, addresses, telephone and fax numbers, and e-mail addresses.

All responses (capability statements) sent in response to this Small Business Sources Sought Notice must be submitted electronically (via e-mail) to the Contract Specialist. Facsimile responses are NOT accepted.

The response must be submitted to Andrea Clay, Contract Specialist at e-mail address amcgee@mail.nih.gov

The response must be received on or before December 26, 2023 at 12:00PM, eastern time.

 “Disclaimer and Important Notes:  This notice does not obligate the Government to award a contract or otherwise pay for the information provided in response. The Government reserves the right to use information provided by respondents for any purpose deemed necessary and legally appropriate. Any organization responding to this notice should ensure that its response is complete and sufficiently detailed to allow the Government to determine the organization’s qualifications to perform the work.

Respondents are advised that the Government is under no obligation to acknowledge receipt of the information received or provide feedback to respondents with respect to any information submitted. After a review of the responses received, a presolicitation synopsis and solicitation may be published in Federal Business Opportunities. However, responses to this notice will not be considered adequate responses to a solicitation.

Confidentiality: No proprietary, classified, confidential, or sensitive information should be included in your response. The Government reserves the right to use any non-proprietary technical information in any resultant solicitation(s).”