Library preparation and next-generation RNA-sequencing of 45 iPSC/IPSC-derived samples

INTRODUCTION

PURSUANT TO FAR Subpart 5.2—Synopses of Proposed Contract Actions, THIS IS A PRE-SOLICITATION NOTICE OF A PROPOSED CONTRACT ACTION.   

THIS IS A PRE-SOLICITATION NON-COMPETITIVE NOTICE OF INTENT TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME). 

The National Center for Advancing Translational Sciences (NCATS) intends to negotiate and award a purchase order without providing for full and open competition (including brand name) to Azenta US, Inc., 2910 Fortune Circle W Ste. E., Indianapolis, IN 46241 for library preparation and next-generation RNA-sequencing of 45 iPSC/IPSC-derived samples.  

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE

The intended procurement is classified under NAICS code 325413 with a Size Standard of 1250.

REGULATORY AUTHORITY

The resultant contract will include all applicable provisions and clauses of the Federal Acquisition Regulation (FAR) in effect through the Federal Acquisition Circular (FAC) 22-2022-06 dated 4/26/2022.

STATUTORY AUTHORITY

This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures, Subpart 13.106-1(b)(1), Soliciting from a single source.

DESCRIPTION OF REQUIREMENT

Project Description

Library preparation and next-generation RNA-sequencing of 45 iPSC/IPSC-derived samples

Purpose and Objectives

Single-cell sequencing is a novel method that allows to derive global transcriptomic profiles - information on the expression level and nature of the transcripts - from each individual cell analyzed. Previously, this was only possible from bulk populations of cells and thus only population-level averages were available. the term "global" refers to the fact that rather than picking a list of genes for targeted analysis, all the detectable transcripts are quantified. These innovations allow for unprecedented detail in studying how genes contribute to disease or how their expression correlates with cellular phenotypes and processes such as differentiation.

Single-cell sequencing methods have become widely used in every project that the SCTL has pursued to date. The SCTL requires library preparation and sequencing service of 45 samples to support ongoing projects.

Period of Performance

Period of Performance is within 12 months after receipt of order.

CLOSING STATEMENT

This synopsis is not a request for competitive proposals.  However, all responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.

Responses to this solicitation must include clear and convincing evidence of the offeror’s capability of fulfilling the requirement as it relates to the technical evaluation criteria.  The price proposal must include the labor categories, an estimate of the number of hours required for each labor category, fully loaded fixed hourly rate or each labor category, breakdown and rationale for other direct costs or materials, and the total amount.

In addition, the Unique Entity Identifier (UEI) issued by the System for Awards Management (SAM.gov), the Taxpayer Identification Number (TIN), and the certification of business size must be included in the response. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov. A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government.  The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.  

Responses must be submitted by email to Rhanda Lopez, at rhanda.lopez@nih.gov no later than September 23, 2022 at 9 a.m. Eastern Standard Time and must reference solicitation number 75N95C22P00120.