Notice of Intent to Sole Source: Generating a THP1 reporter cell line and a 802-30F cell line for high-throughput screening
General Information
- Contract Opportunity Type: Special Notice (Original)
- Original Published Date: Aug 20, 2024 12:03 pm EDT
- Original Response Date: Aug 23, 2024 12:00 pm EDT
- Inactive Policy: 15 days after response date
- Original Inactive Date: Sep 07, 2024
- Initiative:
- None
Classification
- Original Set Aside:
- Product Service Code: Q301 - REFERENCE LABORATORY TESTING
- NAICS Code:
- Place of Performance:
Description
INTRODUCTION
THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME).
The National Institute on Drug Abuse (NIDA), Office of Acquisition (OA) the National Center for Advancing Translational Sciences (NCATS), intends to negotiate and award a purchase order without providing for full and open competition (including brand-name) to EditCo Bio 600 Saginaw DriveRedwood City, CA 94063 for custom lab services for Generating a THP1 reporter cell line and a 802-30F cell line for high-throughput screening.
NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE and SET ASIDE STATUS
The intended procurement is classified under NAICS code 541380 Testing Laboratories and Services with a Size Standard of $16.50.
REGULATORY AUTHORITY
This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13—Simplified Acquisition Procedures. Contracts awarded using FAR Part 13—Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6—Competition Requirements. FAR Subpart 13.106-1 (b) Soliciting from a single source provides that: For purchases not exceeding the simplified acquisition threshold, Contracting officers may solicit from one source IF the contracting officer determines that the circumstances of the contract action deem only one source reasonably available (e.g., urgency, exclusive licensing agreements, brand-name OR industrial mobilization).
The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2022-08 dated October 22, 2022.
DESCRIPTION OF REQUIREMENT
PURPOSE AND OBJECTIVES:
The purpose of this project is to generate THP1 and 802-30F cell lines expressing pro-inflammatory signaling reporters (IL6, CXCL10) fused to a HiBiT luminescent tag.
Contractor will use CRISPR/Cas9 to engineer a HiBiT tag into IL6 and CXCL10 loci. Five pools will be generated.
IL6 (P05231) https://www.uniprot.org/uniprotkb/P05231/entry
KI location: Between Pro29 and Val30
KI sequence: VSGWRLFKKISGGGS
Gene: IL6 (P05231) https://www.uniprot.org/uniprotkb/P05231/entry
KI location: Cterm, following Met212
KI sequence: GGGSVSGWRLFKKIS(STOP)
Gene: CXCL10 (P02778) https://www.uniprot.org/uniprotkb/P02778/entry
KI location: Between Gly21 and Val22
KI sequence: VSGWRLFKKISGGGS
Gene: CXCL10 (P02778) https://www.uniprot.org/uniprotkb/P02778/entry
KI location: Cterm, following Pro98
KI sequence: GGGSVSGWRLFKKIS(STOP)
Gene: IL6
KI location: Cterm,
KI sequence: GGCGGCGGCAGCGTGAGCGGCTGGCGCCTGTTTAAAAAAATTAGC
ESTIMATED PERIOD OF PERFORMANCE:
15 weeks ARO
CONTRACTING WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME) DETERMINATION
The determination by the Government to award a contract without providing for full and open competition is based upon the market research conducted. Specifically, EditCo Bio 600 Saginaw DriveRedwood City, CA 94063 is the only vendor in the marketplace that can provide the services required by NIDA .
The intended source is:
EditCo Bio 600 Saginaw DriveRedwood City, CA 94063
CLOSING STATEMENT
THIS SYNOPSIS IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. However, interested parties may identify their interest and capability to respond to this notice.
A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. All responsible sources may submit a capability statement, proposal, or quotation which shall be considered by the agency. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.
Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include: unit price, list price, shipping and handling costs, the delivery period after contract award, the prompt payment discount terms, the F.O.B. Point (Destination or Origin), the Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.
All responses must be received by the closing date and time of this announcement and must reference the solicitation number, 75N95024Q00532. Responses must be submitted electronically to Kaitlyn Landi, Contract Specialist, at kaitlyn.landi@nih.gov and KJ Shaikh, Contracting Officer, at kj.shaikh@nih.gov. U.S. Mail and fax responses will not be accepted.
Attachments/Links
Contact Information
Contracting Office Address
- c/o 3WFN MSC 6012 301 N Stonestreet Ave
- Bethesda , MD 20892
- USA
Primary Point of Contact
Secondary Point of Contact
History
- Sep 07, 2024 11:55 pm EDTSpecial Notice (Original)