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Prediction and Protection of Intracranial Hypertension and Tissue Hypoxia in Severe Traumatic Brain Injury

Award Details

  • Contract Award Date: Sep 13, 2022
  • Contract Award Number: W81XWH-22-C-0058
  • Task/Delivery Order Number:
  • Contractor Awarded Unique Entity ID: ZUE9HKT2CLC9
  • Contractor Awarded Name: UNIVERSITY OF CHICAGO
  • Contractor Awarded Address: Chicago, IL 60637-5418 USA
  • Base and All Options Value (Total Contract Value): $744,044.00

General Information

  • Contract Opportunity Type: Award Notice (Original)
  • Original Published Date: Sep 14, 2022 05:25 am EDT
  • Inactive Policy: 15 days after contract award date
  • Original Inactive Date: Sep 28, 2022
  • Initiative:
    • None

Classification

  • Original Set Aside:
  • Product Service Code: AN12 - HEALTH R&D SERVICES; HEALTH CARE SERVICES; APPLIED RESEARCH
  • NAICS Code:
    • 541715 - Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology)
  • Place of Performance:
    USA

Description

Phase 1 of this research study aims to establish real-time online capability of predicting high ICP, and/or low PbtO2, collectively referred to as “SBI crises”, via the creation of a virtual monitor (VM). Phase 2 will assess the predictive performance of our crisis-prediction algorithms and VM, in an observational prospective study. The University of Chicago has already shown high accuracy of their predictive algorithms from a retrospective analysis of prospectively collected physiologic data in a database of 817 TBI patients. In phase 3 they will pilot test an SBI pre-emptive clinical management protocol based on predictive alerts. The hypothesis is that this clinical algorithm will reduce the burden of intracranial hypertension and brain tissue hypoxia in patients with TBI. This contract was awarded as a Cost (no fee).

Contact Information

Contracting Office Address

  • BLDG 820 PBO 820 CHANDLER STREET
  • FORT DETRICK , MD 21702-5014
  • USA

Primary Point of Contact

Secondary Point of Contact





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